February 2026

Papers:

From sequence to function: Bridging single-molecule kinetics and molecular diversity

Kapanidis A.N. et al. 2026. Science 391: 458-65.

As a graduate student, I remember critiquing a single-molecule paper and a peer mentioning the low N. The professor (a SM expert) immediately pointed out how much time it probably took to get that many N. With SM experience of my own, I deeply appreciate now the work that goes into SM experiments. It's great to have a review highlighting how we can multiplex some of these experiments and garner even more information.

The cell as a collection of protein machines: Preparing the next generation of molecular biologists

Alberts, B. 1998. Cell 92: 291-294.

I have always been fascinated with how cells manage to coordinate the seeming randomness of molecular biology to achieve specific functions. This extends beyond the protein machines so elegantly described in this overview to include using noise to their advantage and complex genetic and biochemical circuits to provide precise outcomes dictated by signaling inputs. As a biophysicist, I of course love to see biology students encouraged to take chemistry and physics, since they open up so many of the cell's mysteries.

Books:

"Project Hail Mary" By Andy Weir

Podcasts:

"Are we turning the tide on superbugs?" from Behind the Science

I'm looking forward to hearing more from the Fleming Initiative in the future. Also, it's great to hear the argument being made for more people to get involved in this VERY impactful field!